PDBe 5un7

X-ray diffraction
2.1Å resolution

Structure of the human POT1-TPP1 telomeric complex

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
hetero tetramer
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Protection of telomeres protein 1 Chain: A
Molecule details ›
Chain: A
Length: 308 amino acids
Theoretical weight: 34.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9NUX5 (Residues: 330-634; Coverage: 48%)
Gene name: POT1
Adrenocortical dysplasia protein homolog Chain: B
Molecule details ›
Chain: B
Length: 86 amino acids
Theoretical weight: 9.2 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q96AP0 (Residues: 255-337; Coverage: 15%)
Gene names: ACD, PIP1, PTOP, TINT1, TPP1

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL12-2
Spacegroup: P4122
Unit cell:
a: 99.53Å b: 99.53Å c: 122.14Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.184 0.182 0.222
Expression system: Escherichia coli