PDBe 5ubt

X-ray diffraction
2.83Å resolution

CRYSTAL STRUCTURE OF PI3K DELTA IN COMPLEX WITH A 7-(3-(PIPERAZIN-1-YL)PHENYL)PYRROLO[2,1-F][1,2,4] TRIAZIN-4-AMINE DERIVIATINE

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform Chain: A
Molecule details ›
Chain: A
Length: 1013 amino acids
Theoretical weight: 115.96 KDa
Source organism: Homo sapiens
Expression system: unidentified baculovirus
UniProt:
  • Canonical: NEW O00329 (Residues: 17-1029; Coverage: 97%)
Gene name: PIK3CD
Sequence domains:
Phosphatidylinositol 3-kinase regulatory subunit alpha Chain: B
Molecule details ›
Chain: B
Length: 168 amino acids
Theoretical weight: 20.72 KDa
Source organism: Homo sapiens
Expression system: unidentified baculovirus
UniProt:
  • Canonical: NEW P27986 (Residues: 432-599; Coverage: 23%)
Gene names: GRB1, PIK3R1

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P212121
Unit cell:
a: 90.662Å b: 108.603Å c: 142.903Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.216 0.215 0.268
Expression system: unidentified baculovirus