PDBe 5u5s

Solution NMR

Solution structures of Brd2 second bromodomain in complex with stat3 peptide

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Bromodomain-containing protein 2 Chain: A
Molecule details ›
Chain: A
Length: 112 amino acids
Theoretical weight: 13.16 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: NEW P25440 (Residues: 344-455; Coverage: 14%)
Gene names: BRD2, KIAA9001, RING3
Sequence domains: Bromodomain
Signal transducer and activator of transcription 3 Chain: B
Molecule details ›
Chain: B
Length: 12 amino acids
Theoretical weight: 1.54 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: NEW P40763 (Residues: 81-92; Coverage: 2%)
Gene names: APRF, STAT3

Ligands and Environments

No bound ligands

1 modified residue:

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 81%
Refinement method: torsion angle dynamics
Chemical shifts: BMR30206  
Expression systems:
  • Escherichia coli
  • Not provided