PDBe 5u2j

X-ray diffraction
1.6Å resolution

MORF double PHD finger (DPF) in complex with histone H3K14bu

Released:
Source organism: Homo sapiens

Function and Biology Details

Reaction catalysed:
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Histone H3.1 Chains: C, D
Molecule details ›
Chains: C, D
Length: 16 amino acids
Theoretical weight: 1.73 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: NEW P68431 (Residues: 2-17; Coverage: 12%)
Gene names: H3FA, H3FB, H3FC, H3FD, H3FF, H3FH, H3FI, H3FJ, H3FK, H3FL, HIST1H3A, HIST1H3B, HIST1H3C, HIST1H3D, HIST1H3E, HIST1H3F, HIST1H3G, HIST1H3H, HIST1H3I, HIST1H3J
Histone acetyltransferase KAT6B Chains: A, B
Molecule details ›
Chains: A, B
Length: 111 amino acids
Theoretical weight: 12.47 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'
UniProt:
  • Canonical: NEW Q8WYB5 (Residues: 211-320; Coverage: 5%)
Gene names: KAT6B, KIAA0383, MORF, MOZ2, MYST4
Sequence domains: PHD-finger

Ligands and Environments

1 bound ligand:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 4.2.2
Spacegroup: P21
Unit cell:
a: 32.54Å b: 69.19Å c: 69.93Å
α: 90° β: 97.16° γ: 90°
R-values:
R R work R free
0.193 0.191 0.238
Expression systems:
  • Not provided
  • Escherichia coli 'BL21-Gold(DE3)pLysS AG'