PDBe 5tz9

X-ray diffraction
1.7Å resolution

Structure of plasma kallikrein protease domain with inhibitor


Function and Biology Details

Reaction catalysed:
Cleaves selectively Arg-|-Xaa and Lys-|-Xaa bonds, including Lys-|-Arg and Arg-|-Ser bonds in (human) kininogen to release bradykinin.
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Plasma kallikrein light chain Chain: E
Molecule details ›
Chain: E
Length: 263 amino acids
Theoretical weight: 29.43 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Canonical: P03952 (Residues: 376-638; Coverage: 43%)
Gene names: KLK3, KLKB1
Sequence domains: Trypsin

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: P212121
Unit cell:
a: 55.685Å b: 57.45Å c: 86.215Å
α: 90° β: 90° γ: 90°
R R work R free
0.184 0.182 0.219
Expression system: Spodoptera frugiperda