PDBe 5t8r

X-ray diffraction
2.4Å resolution

Crystal structure of human BAZ2A PHD zinc finger in complex with unmodified H3 10-mer

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
hetero dimer
monomeric
hetero trimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Bromodomain adjacent to zinc finger domain protein 2A Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 58 amino acids
Theoretical weight: 6.6 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: NEW Q9UIF9 (Residues: 1673-1728; Coverage: 3%)
Gene names: BAZ2A, KIAA0314, TIP5
Sequence domains: PHD-finger
Histone H3.1 Chains: E, G
Molecule details ›
Chains: E, G
Length: 10 amino acids
Theoretical weight: 1.15 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: NEW P68431 (Residues: 2-11; Coverage: 7%)
Gene names: H3FA, H3FB, H3FC, H3FD, H3FF, H3FH, H3FI, H3FJ, H3FK, H3FL, HIST1H3A, HIST1H3B, HIST1H3C, HIST1H3D, HIST1H3E, HIST1H3F, HIST1H3G, HIST1H3H, HIST1H3I, HIST1H3J

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P43212
Unit cell:
a: 72.607Å b: 72.607Å c: 99.431Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.188 0.185 0.235
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided