PDBe 5sxk

X-ray diffraction
3.55Å resolution

Crystal Structure of PI3Kalpha in complex with fragment 18

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Chain: A
Molecule details ›
Chain: A
Length: 1096 amino acids
Theoretical weight: 127.9 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P42336 (Residues: 1-1068; Coverage: 100%)
Gene name: PIK3CA
Sequence domains:
Phosphatidylinositol 3-kinase regulatory subunit alpha Chain: B
Molecule details ›
Chain: B
Length: 279 amino acids
Theoretical weight: 33.67 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P27986 (Residues: 322-600; Coverage: 39%)
Gene names: GRB1, PIK3R1
Sequence domains:

Ligands and Environments

1 bound ligand:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 31-ID
Spacegroup: P212121
Unit cell:
a: 113.282Å b: 115.838Å c: 148.999Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.198 0.193 0.278
Expression system: Spodoptera frugiperda