PDBe 5sx4

X-ray diffraction
2.8Å resolution

Crystal Structure of panitumumab in complex with epidermal growth factor receptor domain 3.

Released:

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Panitumumab Fab Light Chain Chains: I, L
Molecule details ›
Chains: I, L
Length: 214 amino acids
Theoretical weight: 23.38 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
Structure domains: Immunoglobulins
Panitumumab Fab Heavy Chain Chains: H, J
Molecule details ›
Chains: H, J
Length: 221 amino acids
Theoretical weight: 23.67 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
Structure domains: Immunoglobulins
Epidermal growth factor receptor Chains: M, N
Molecule details ›
Chains: M, N
Length: 201 amino acids
Theoretical weight: 22.28 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P00533 (Residues: 335-525; Coverage: 16%)
Gene names: EGFR, ERBB, ERBB1, HER1
Sequence domains: Receptor L domain
Structure domains: Receptor L-domain

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P212121
Unit cell:
a: 65.273Å b: 113.184Å c: 232.443Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.226 0.223 0.266
Expression systems:
  • Cricetulus griseus
  • Spodoptera frugiperda