PDBe 5svp

X-ray diffraction
3.3Å resolution

Anomalous sulfur signal reveals the position of agonist 2-methylthio-ATP bound to the ATP-gated human P2X3 ion channel in the desensitized state


Function and Biology Details

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Entry contents:
1 distinct polypeptide molecule
P2X purinoceptor 3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 363 amino acids
Theoretical weight: 40.72 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
  • Canonical: P56373 (Residues: 6-364; Coverage: 90%)
Gene name: P2RX3

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P213
Unit cell:
a: 172.93Å b: 172.93Å c: 172.93Å
α: 90° β: 90° γ: 90°
R R work R free
0.204 0.202 0.227
Expression system: Homo sapiens