› 5owq

X-ray diffraction
2.7Å resolution

Human STK10 bound to dovitinib

Released:
DOI: 10.2210/pdb5owq/pdb
PDB entry 5owq coloured by chain, front view.
PDB entry 5owq coloured by chain, side view.
PDB entry 5owq coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Szklarz M, von Delft F, Bountra C, Knapp S, Edwards AM, Arrowsmith C, Elkins JM

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-131759 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase 10 Chains: A, B
Molecule details ›
Chains: A, B
Length: 302 amino acids
Theoretical weight: 34.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O94804 (Residues: 18-317; Coverage: 31%)
Gene names: LOK, STK10
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand 38O 2 x 38O
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: P21
Unit cell:
a: 57.57Å b: 50.4Å c: 114.57Å
α: 90° β: 96.6° γ: 90°
R-values:
R R work R free
0.265 0.263 0.305
Expression system: Escherichia coli BL21(DE3)

Quick links