PDBe 5ocy

X-ray diffraction
2.6Å resolution

Crystal structure of ACPA E4 in complex with CII-C-48-CIT

Released:
Source organism: Homo sapiens
Entry authors: Dobritzsch D, Ge C, Holmdahl R

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
ACPA E4 Fab fragment - heavy chain Chain: H
Molecule details ›
Chain: H
Length: 220 amino acids
Theoretical weight: 23.36 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
ACPA E4 Fab fragment - light chain Chain: L
Molecule details ›
Chain: L
Length: 216 amino acids
Theoretical weight: 23.26 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Collagen alpha-1(II) chain Chain: C
Molecule details ›
Chain: C
Length: 18 amino acids
Theoretical weight: 1.83 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P02458 (Residues: 1120-1134; Coverage: 1%)
Gene name: COL2A1

Ligands and Environments

No bound ligands

2 modified residues:

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: P212121
Unit cell:
a: 46.13Å b: 99.048Å c: 100.33Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.19 0.187 0.245
Expression systems:
  • Homo sapiens
  • Not provided