PDBe 5ocx

X-ray diffraction
1.75Å resolution

Crystal structure of ACPA E4 in complex with CII-C-13-CIT

Released:
Source organism: Homo sapiens
Entry authors: Dobritzsch D, Ge C, Holmdahl R

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Fab fragment anti-citrullinated protein antibody E4 - light chain Chain: L
Molecule details ›
Chain: L
Length: 217 amino acids
Theoretical weight: 23.62 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Fab fragment of anti-citrullinated protein antibody E4 - heavy chain Chain: H
Molecule details ›
Chain: H
Length: 221 amino acids
Theoretical weight: 23.45 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Collagen alpha-1(II) chain Chain: A
Molecule details ›
Chain: A
Length: 18 amino acids
Theoretical weight: 1.75 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P02458 (Residues: 484-498; Coverage: 1%)
Gene name: COL2A1

Ligands and Environments

1 bound ligand:

2 modified residues:

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: P21
Unit cell:
a: 38.716Å b: 99.602Å c: 51.877Å
α: 90° β: 101.88° γ: 90°
R-values:
R R work R free
0.178 0.176 0.212
Expression systems:
  • Homo sapiens
  • Not provided