PDBe 5o2p

Solution NMR

p130Cas SH3 domain PTP-PEST peptide chimera


Function and Biology Details

Reaction catalysed:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Breast cancer anti-estrogen resistance protein 1; Tyrosine-protein phosphatase non-receptor type 12 Chain: A
Molecule details ›
Chain: A
Length: 100 amino acids
Theoretical weight: 10.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P56945 (Residues: 4-73; Coverage: 8%)
  • Canonical: Q05209 (Residues: 328-344; Coverage: 2%)
  • nullnull
Gene names: BCAR1, CAS, CASS1, CRKAS, PTPN12
Sequence domains: SH3 domain

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 91%
Refinement method: simulated annealing
Chemical shifts: BMR34142  
Expression system: Escherichia coli