PDBe 5nmv

X-ray diffraction
1.65Å resolution

Crystal structure of 2F22 Fab fragment against TFPI1

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Fab light chain Chain: L
Molecule details ›
Chain: L
Length: 213 amino acids
Theoretical weight: 23.24 KDa
Source organism: Mus
Expression system: Homo sapiens
Fab heavy chain Chain: H
Molecule details ›
Chain: H
Length: 222 amino acids
Theoretical weight: 23.81 KDa
Source organism: Mus
Expression system: Homo sapiens
Tissue factor pathway inhibitor Chain: K
Molecule details ›
Chain: K
Length: 86 amino acids
Theoretical weight: 9.8 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P10646 (Residues: 29-107; Coverage: 29%)
Gene names: LACI, TFPI, TFPI1
Sequence domains: Kunitz/Bovine pancreatic trypsin inhibitor domain

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MAX II BEAMLINE I911-3
Spacegroup: C2
Unit cell:
a: 89.01Å b: 66.66Å c: 106.11Å
α: 90° β: 111.18° γ: 90°
R-values:
R R work R free
0.177 0.175 0.202
Expression system: Homo sapiens