PDBe 5nme

X-ray diffraction
2.94Å resolution

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
HLA class I histocompatibility antigen, A-2 alpha chain Chains: A, F
Molecule details ›
Chains: A, F
Length: 276 amino acids
Theoretical weight: 31.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01892 (Residues: 25-300; Coverage: 81%)
Gene names: HLA-A, HLAA
Sequence domains:
Beta-2-microglobulin Chains: B, G
Molecule details ›
Chains: B, G
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Matrix protein p17 Chains: C, H
Molecule details ›
Chains: C, H
Length: 9 amino acids
Theoretical weight: 981 Da
Source organism: Human immunodeficiency virus 1
Expression system: Not provided
UniProt:
  • Canonical: P04591 (Residues: 77-85; Coverage: 2%)
Gene name: gag
T-cell receptor Alpha chain Chains: D, I
Molecule details ›
Chains: D, I
Length: 201 amino acids
Theoretical weight: 22.32 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
Human T-cell receptor beta chain Chains: E, J
Molecule details ›
Chains: E, J
Length: 242 amino acids
Theoretical weight: 27.44 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P21212
Unit cell:
a: 211.14Å b: 85.14Å c: 113.19Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.199 0.196 0.263
Expression systems:
  • Escherichia coli
  • Not provided