PDBe 5njd

X-ray diffraction
3.9Å resolution

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Interleukin-12 subunit beta Chains: A, C, E, G, I, K
Molecule details ›
Chains: A, C, E, G, I, K
Length: 328 amino acids
Theoretical weight: 37.21 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P29460 (Residues: 1-328; Coverage: 100%)
Gene names: IL12B, NKSF2
Sequence domains: Cytokine interleukin-12p40 C-terminus
Interleukin-23 subunit alpha Chains: B, D, F, H, J, L
Molecule details ›
Chains: B, D, F, H, J, L
Length: 198 amino acids
Theoretical weight: 21.87 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9NPF7 (Residues: 1-189; Coverage: 100%)
Gene names: IL23A, SGRF, UNQ2498/PRO5798
Sequence domains: Interleukin 23 subunit alpha
Briakinumab FAb Light chain Chains: M, O, Q, S, U, W
Molecule details ›
Chains: M, O, Q, S, U, W
Length: 245 amino acids
Theoretical weight: 25.93 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Briakinumab FAb Heavy chain Chains: N, P, R, T, V, X
Molecule details ›
Chains: N, P, R, T, V, X
Length: 289 amino acids
Theoretical weight: 30.72 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PETRA III, EMBL c/o DESY BEAMLINE P14 (MX2)
Spacegroup: P41212
Unit cell:
a: 191.606Å b: 191.606Å c: 519.109Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.272 0.272 0.312
Expression system: Homo sapiens