PDBe 5ng3

X-ray diffraction
2.6Å resolution

Structure of inactive kinase RIP2K(K47R)

Released:

Function and Biology Details

Reactions catalysed:
ATP + a protein = ADP + a phosphoprotein
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Receptor-interacting serine/threonine-protein kinase 2 Chains: A, D
Molecule details ›
Chains: A, D
Length: 304 amino acids
Theoretical weight: 34.92 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O43353 (Residues: 1-300; Coverage: 56%)
  • Best match: O43353-2 (Residues: 1-163)
Gene names: CARDIAK, RICK, RIP2, RIPK2, UNQ277/PRO314/PRO34092
Sequence domains: Protein tyrosine kinase
Receptor-interacting serine/threonine-protein kinase 2 Chains: B, C
Molecule details ›
Chains: B, C
Length: 304 amino acids
Theoretical weight: 34.84 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O43353 (Residues: 1-300; Coverage: 56%)
  • Best match: O43353-2 (Residues: 1-163)
Gene names: CARDIAK, RICK, RIP2, RIPK2, UNQ277/PRO314/PRO34092
Sequence domains: Protein tyrosine kinase

Ligands and Environments

1 bound ligand:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P212121
Unit cell:
a: 77.022Å b: 103.31Å c: 204.299Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.234 0.232 0.269
Expression system: Spodoptera frugiperda