› 5mwy

X-ray diffraction
1.75Å resolution

Function and Biology Details

Reaction catalysed: 
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140040 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Mineralocorticoid receptor Chain: A
Molecule details ›
Chain: A
Length: 305 amino acids
Theoretical weight: 34.81 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P08235 (Residues: 735-984; Coverage: 25%)
Gene names: MCR, MLR, NR3C2
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor
Nuclear receptor coactivator 1 Chain: B
Molecule details ›
Chain: B
Length: 15 amino acids
Theoretical weight: 1.73 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q15788 (Residues: 1427-1441; Coverage: 1%)
Gene names: BHLHE74, NCOA1, SRC1

Ligands and Environments

1 bound ligand:
Ligand YNU 1 x YNU
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P212121
Unit cell:
a: 48.538Å b: 77.944Å c: 78.917Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.23 0.229 0.245
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

8 review citations

Mineralocorticoid receptor antagonists in diabetic kidney disease - mechanistic and therapeutic effects.
Barrera-Chimal et al. (2022)
7 more

3 mentions without citation

Preclinical pharmacology of AZD9977: A novel mineralocorticoid receptor modulator separating organ protection from effects on electrolyte excretion.
Bamberg et al. (2018)
2 more