PDBe 5mf0

X-ray diffraction
3.03Å resolution

Crystal structure of Smad4-MH1 bound to the GGCCG site.


Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct DNA molecule
Macromolecules (2 distinct):
Mothers against decapentaplegic homolog 4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 135 amino acids
Theoretical weight: 15.24 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: NEW Q13485 (Residues: 10-140; Coverage: 24%)
Gene names: DPC4, MADH4, SMAD4
Sequence domains: MH1 domain
Molecule details ›
Chains: E, F
Length: 16 nucleotides
Theoretical weight: 4.9 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: P43
Unit cell:
a: 101.52Å b: 101.52Å c: 45.78Å
α: 90° β: 90° γ: 90°
R R work R free
0.232 0.231 0.27
Expression systems:
  • Escherichia coli
  • Not provided