PDBe 5mey

X-ray diffraction
2.05Å resolution

Crystal structure of Smad4-MH1 bound to the GGCGC site.


Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct DNA molecule
Macromolecules (2 distinct):
Mothers against decapentaplegic homolog 4 Chain: A
Molecule details ›
Chain: A
Length: 135 amino acids
Theoretical weight: 15.24 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q13485 (Residues: 10-140; Coverage: 24%)
Gene names: DPC4, MADH4, SMAD4
Sequence domains: MH1 domain
Molecule details ›
Chain: D
Length: 18 nucleotides
Theoretical weight: 5.52 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: C2221
Unit cell:
a: 64.17Å b: 79Å c: 90.1Å
α: 90° β: 90° γ: 90°
R R work R free
0.223 0.222 0.238
Expression systems:
  • Escherichia coli
  • Not provided