PDBe 5m6u

X-ray diffraction
2.85Å resolution

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform Chain: A
Molecule details ›
Chain: A
Length: 1011 amino acids
Theoretical weight: 115.73 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: NEW O00329 (Residues: 17-1027; Coverage: 97%)
Gene name: PIK3CD
Sequence domains:
Phosphatidylinositol 3-kinase regulatory subunit alpha Chain: B
Molecule details ›
Chain: B
Length: 724 amino acids
Theoretical weight: 83.67 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: NEW P27986 (Residues: 1-724; Coverage: 100%)
Gene names: GRB1, PIK3R1
Sequence domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P212121
Unit cell:
a: 92.493Å b: 113.212Å c: 144.321Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.257 0.256 0.309
Expression system: Spodoptera frugiperda