PDBe 5ly1

X-ray diffraction
2.5Å resolution

JMJD2A/ KDM4A COMPLEXED WITH NI(II) AND Macrocyclic PEPTIDE Inhibitor CP2 (13-mer)

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
CP2 Chain: E
Molecule details ›
Chain: E
Length: 14 amino acids
Theoretical weight: 1.91 KDa
Source organism: artificial sequences
Expression system: Not provided
Lysine-specific demethylase 4A Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 381 amino acids
Theoretical weight: 44.33 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O75164 (Residues: 1-359; Coverage: 34%)
Gene names: JHDM3A, JMJD2, JMJD2A, KDM4A, KIAA0677
Sequence domains:

Ligands and Environments


1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: P21
Unit cell:
a: 57.265Å b: 101.482Å c: 140.33Å
α: 90° β: 99.56° γ: 90°
R-values:
R R work R free
0.18 0.178 0.205
Expression systems:
  • Not provided
  • Escherichia coli BL21(DE3)