PDBe 5luq

X-ray diffraction
4.3Å resolution

Crystal Structure of Human DNA-dependent Protein Kinase Catalytic Subunit (DNA-PKcs)

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
DNA-dependent protein kinase catalytic subunit Chains: A, B
Molecule details ›
Chains: A, B
Length: 4128 amino acids
Theoretical weight: 469.62 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P78527 (Residues: 2-4127; Coverage: 100%)
Gene names: HYRC, HYRC1, PRKDC
Sequence domains:
C-terminal fragment of KU80 (KU80ct194) Chains: K, S
Molecule details ›
Chains: K, S
Length: 194 amino acids
Theoretical weight: 16.62 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)

Ligands and Environments

No bound ligands

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29, ESRF BEAMLINE ID23-1
Spacegroup: P21
Unit cell:
a: 169.12Å b: 132.64Å c: 296.59Å
α: 90° β: 105.53° γ: 90°
R-values:
R R work R free
0.387 0.386 0.437
Expression system: Escherichia coli BL21(DE3)