PDBe 5l7h

X-ray diffraction
1.84Å resolution

Function and Biology Details

Reaction catalysed:
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Mineralocorticoid receptor Chain: A
Molecule details ›
Chain: A
Length: 305 amino acids
Theoretical weight: 34.83 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P08235 (Residues: 735-984; Coverage: 25%)
  • Best match: P08235-4 (Residues: 670-867)
Gene names: MCR, MLR, NR3C2
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor
Nuclear receptor coactivator 1 Chain: B
Molecule details ›
Chain: B
Length: 10 amino acids
Theoretical weight: 1.17 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q15788 (Residues: 1432-1441; Coverage: 1%)
Gene names: BHLHE74, NCOA1, SRC1

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P212121
Unit cell:
a: 48.67Å b: 77.89Å c: 78.62Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.195 0.194 0.224
Expression system: Escherichia coli BL21