PDBe 5l0j

X-ray diffraction
4Å resolution

Human vinculin R903Q, D907R, R910T mutant(residues 891-1066)

Released:
Source organism: Homo sapiens
Primary publication:
Differential lipid binding of vinculin isoforms promotes quasi-equivalent dimerization.
Proc. Natl. Acad. Sci. U.S.A. 113 9539-44 (2016)
PMID: 27503891

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Vinculin Chains: A, B
Molecule details ›
Chains: A, B
Length: 176 amino acids
Theoretical weight: 19.72 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P18206 (Residues: 962-1134; Coverage: 15%)
  • Best match: P18206-2 (Residues: 891-1066)
Gene name: VCL
Structure domains: Alpha-catenin/vinculin-like

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL12-2
Spacegroup: P3221
Unit cell:
a: 86.43Å b: 86.43Å c: 175.28Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.293 0.293 0.298
Expression system: Escherichia coli BL21(DE3)