PDBe 5kyn

X-ray diffraction
2.55Å resolution

Structure of Sec23 and TANGO1 complex

Source organism: Homo sapiens
Primary publication:
TANGO1/cTAGE5 receptor as a polyvalent template for assembly of large COPII coats.
Proc. Natl. Acad. Sci. U.S.A. (2016)
PMID: 27551091

Function and Biology Details

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Protein transport protein Sec23A Chains: A, B
Molecule details ›
Chains: A, B
Length: 765 amino acids
Theoretical weight: 86.25 KDa
Source organism: Homo sapiens
Expression system: Insect cell expression vector pTIE1
  • Canonical: Q15436 (Residues: 1-765; Coverage: 100%)
Gene name: SEC23A
Sequence domains:
Structure domains:
Transport and Golgi organization protein 1 homolog Chain: C
Molecule details ›
Chain: C
Length: 8 amino acids
Theoretical weight: 831 Da
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q5JRA6 (Residues: 1796-1803; Coverage: 0%)
Gene names: KIAA0268, MIA3, TANGO, UNQ6077/PRO20088

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: C2
Unit cell:
a: 133.454Å b: 65.88Å c: 229.871Å
α: 90° β: 97.39° γ: 90°
R R work R free
0.202 0.2 0.246
Expression systems:
  • Insect cell expression vector pTIE1
  • Escherichia coli