PDBe 5jtw

X-ray diffraction
3.5Å resolution

Crystal structure of complement C4b re-refined using iMDFF

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Complement C4 beta chain Chains: A, D
Molecule details ›
Chains: A, D
Length: 656 amino acids
Theoretical weight: 71.76 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P0C0L4 (Residues: 20-675; Coverage: 38%)
Gene names: C4A, CO4, CPAMD2
Sequence domains:
Structure domains:
C4b-A Chains: B, E
Molecule details ›
Chains: B, E
Length: 690 amino acids
Theoretical weight: 75.51 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P0C0L4 (Residues: 757-1446; Coverage: 40%)
Gene names: C4A, CO4, CPAMD2
Sequence domains:
Complement C4 gamma chain Chains: C, F
Molecule details ›
Chains: C, F
Length: 291 amino acids
Theoretical weight: 33.12 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P0C0L4 (Residues: 1454-1744; Coverage: 17%)
Gene names: C4A, CO4, CPAMD2
Sequence domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P21
Unit cell:
a: 121.5Å b: 161.08Å c: 131.6Å
α: 90° β: 107.26° γ: 90°
R-values:
R R work R free
0.25 0.248 0.294