PDBe 5jpn

X-ray diffraction
3.6Å resolution

Structure of human complement C4 rebuilt using iMDFF

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Complement C4 beta chain Chain: A
Molecule details ›
Chain: A
Length: 656 amino acids
Theoretical weight: 71.76 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P0C0L4 (Residues: 20-675; Coverage: 38%)
Gene names: C4A, CO4, CPAMD2
Sequence domains:
Structure domains:
Complement C4-A alpha chain Chain: B
Complement C4 gamma chain Chain: C
Molecule details ›
Chain: C
Length: 290 amino acids
Theoretical weight: 32.99 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P0C0L4 (Residues: 1455-1744; Coverage: 17%)
Gene names: C4A, CO4, CPAMD2
Sequence domains:
Structure domains:

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 1, ESRF BEAMLINE ID29
Spacegroup: P212121
Unit cell:
a: 85.45Å b: 103.31Å c: 256.03Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.217 0.215 0.263