› 5jho

X-ray diffraction
2.8Å resolution

Crystal structure of the regulatory domain of the sodium driven chloride bicarbonate exchanger.

Released:
DOI: 10.2210/pdb5jho/pdb
PDB entry 5jho coloured by chain, front view.
PDB entry 5jho coloured by chain, side view.
PDB entry 5jho coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The crystal structure of the regulatory domain of the human sodium-driven chloride/bicarbonate exchanger.
Alvadia CM, Sommer T, Bjerregaard-Andersen K, Damkier HH, Montrasio M, Aalkjaer C, Morth JP
Sci Rep 7 12131 (2017)
PMID: 28935959

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-174131 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Electroneutral sodium bicarbonate exchanger 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 344 amino acids
Theoretical weight: 38.91 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q2Y0W8 (Residues: 54-397; Coverage: 32%)
Gene names: KIAA0739, NBC, NBC3, NDCBE1, SLC4A8
Sequence domains: Band 3 cytoplasmic domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: P4322
Unit cell:
a: 98.04Å b: 98.04Å c: 212.87Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.202 0.2 0.238
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

2 review citations

Protons as Messengers of Intercellular Communication in the Nervous System.
Soto et al. (2018)
1 more

2 mentions without citation

The crystal structure of the regulatory domain of the human sodium-driven chloride/bicarbonate exchanger.
Alvadia et al. (2017)
1 more