PDBe 5jem

X-ray diffraction
2.5Å resolution

Complex of IRF-3 with CBP

Released:
Source organism: Homo sapiens

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Interferon regulatory factor 3 Chains: A, B, E, G
Molecule details ›
Chains: A, B, E, G
Length: 213 amino acids
Theoretical weight: 23.77 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14653 (Residues: 189-398; Coverage: 49%)
  • Best match: Q14653-4 (Residues: 189-327)
Gene name: IRF3
Sequence domains: Interferon-regulatory factor 3
Structure domains: Tumour Suppressor Smad4
CREB-binding protein Chains: C, D, F, H
Molecule details ›
Chains: C, D, F, H
Length: 47 amino acids
Theoretical weight: 5.27 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q92793 (Residues: 2065-2111; Coverage: 2%)
Gene names: CBP, CREBBP
Structure domains: Nuclear receptor coactivator, CREB-bp-like, interlocking domain

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007
Spacegroup: P21
Unit cell:
a: 85.23Å b: 88.66Å c: 92.81Å
α: 90° β: 113.09° γ: 90°
R-values:
R R work R free
0.194 0.192 0.242
Expression system: Escherichia coli