PDBe 5jel

X-ray diffraction
1.6Å resolution

Phosphorylated TRIF in complex with IRF-3

Released:
Source organism: Homo sapiens

Function and Biology Details

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
hetero tetramer
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Interferon regulatory factor 3 Chain: A
Molecule details ›
Chain: A
Length: 242 amino acids
Theoretical weight: 26.9 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14653 (Residues: 189-427; Coverage: 56%)
Gene name: IRF3
Sequence domains: Interferon-regulatory factor 3
Structure domains: Tumour Suppressor Smad4
TIR domain-containing adapter molecule 1 Chain: B
Molecule details ›
Chain: B
Length: 21 amino acids
Theoretical weight: 2.49 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8IUC6 (Residues: 199-219; Coverage: 3%)
Gene names: PRVTIRB, TICAM1, TRIF

Ligands and Environments

No bound ligands

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.1
Spacegroup: P3221
Unit cell:
a: 72.811Å b: 72.811Å c: 127.602Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.169 0.168 0.187
Expression system: Escherichia coli