PDBe 5j9s

X-ray diffraction
2.7Å resolution

ENL YEATS in complex with histone H3 acetylation at K27

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Protein ENL Chain: A
Molecule details ›
Chain: A
Length: 155 amino acids
Theoretical weight: 18.31 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q03111 (Residues: 1-148; Coverage: 27%)
Gene names: ENL, LTG19, MLLT1, YEATS1
Sequence domains: YEATS family
Histone H3.1 Chain: B
Molecule details ›
Chain: B
Length: 25 amino acids
Theoretical weight: 2.62 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P68431 (Residues: 16-40; Coverage: 18%)
Gene names: H3FA, H3FB, H3FC, H3FD, H3FF, H3FH, H3FI, H3FJ, H3FK, H3FL, HIST1H3A, HIST1H3B, HIST1H3C, HIST1H3D, HIST1H3E, HIST1H3F, HIST1H3G, HIST1H3H, HIST1H3I, HIST1H3J

Ligands and Environments

1 bound ligand:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P3121
Unit cell:
a: 104.979Å b: 104.979Å c: 45.128Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.187 0.185 0.21
Expression systems:
  • Escherichia coli BL21
  • Not provided