PDBe 5iql

X-ray diffraction
2.1Å resolution

Crystal structure of YEATS2 YEATS bound to H3K27cr peptide

Released:
Source organism: Homo sapiens
Primary publication:
YEATS2 is a selective histone crotonylation reader.
OpenAccess logo Cell Res. 26 629-32 (2016)
PMID: 27103431

Function and Biology Details

Biochemical function:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
YEATS domain-containing protein 2 Chain: A
Molecule details ›
Chain: A
Length: 133 amino acids
Theoretical weight: 15.82 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9ULM3 (Residues: 201-332; Coverage: 9%)
Gene names: KIAA1197, YEATS2
Sequence domains: YEATS family
Structure domains: Immunoglobulin-like
Histone H3.1 Chain: B
Molecule details ›
Chain: B
Length: 8 amino acids
Theoretical weight: 840 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P68431 (Residues: 25-32; Coverage: 6%)
Gene names: H3FA, H3FB, H3FC, H3FD, H3FF, H3FH, H3FI, H3FJ, H3FK, H3FL, HIST1H3A, HIST1H3B, HIST1H3C, HIST1H3D, HIST1H3E, HIST1H3F, HIST1H3G, HIST1H3H, HIST1H3I, HIST1H3J

Ligands and Environments

No bound ligands

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: I422
Unit cell:
a: 75.791Å b: 75.791Å c: 119.331Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.209 0.204 0.253
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided