PDBe 5ikw

X-ray diffraction
2.41Å resolution

Crystal Structure of BMP-2-inducible kinase in complex with an Indazole inhibitor

Source organism: Homo sapiens
Entry authors: Counago RM, Sorrell FJ, Krojer T, Savitsky P, Elkins JM, Axtman A, Drewry D, Wells C, Zhang C, Zuercher W, Willson TM, Arrowsmith CH, Edwards AM, Bountra C, Arruda P, Gileadi O, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
BMP-2-inducible protein kinase Chain: A
Molecule details ›
Chain: A
Length: 310 amino acids
Theoretical weight: 34.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: Q9NSY1 (Residues: 38-345; Coverage: 27%)
Gene names: BIKE, BMP2K, HRIHFB2017
Sequence domains: Protein kinase domain

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: I222
Unit cell:
a: 41.957Å b: 111.155Å c: 164.053Å
α: 90° β: 90° γ: 90°
R R work R free
0.178 0.176 0.216
Expression system: Escherichia coli BL21(DE3)