PDBe 5i6u

X-ray diffraction
2.84Å resolution

The crystal structure of PI3Kdelta with compound 32

Source organism: Mus musculus
Entry authors: Somoza JR, Villasenor AG

Function and Biology Details

Reaction catalysed:
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform Chain: A
Molecule details ›
Chain: A
Length: 939 amino acids
Theoretical weight: 107.77 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
  • Canonical: O35904 (Residues: 106-507, 509-1043; Coverage: 90%)
Gene name: Pik3cd
Sequence domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.1
Spacegroup: C2
Unit cell:
a: 142.836Å b: 64.926Å c: 117.058Å
α: 90° β: 103.172° γ: 90°
R R work R free
0.22 0.212 0.307
Expression system: Spodoptera frugiperda