PDBe 5i4v

X-ray diffraction
2.61Å resolution

Discovery of novel, orally efficacious Liver X Receptor (LXR) beta agonists

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Oxysterols receptor LXR-beta; Nuclear receptor coactivator 2 Chains: A, E
Molecule details ›
Chains: A, E
Length: 270 amino acids
Theoretical weight: 30.57 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q15596 (Residues: 687-699; Coverage: 1%)
  • Canonical: P55055 (Residues: 210-460; Coverage: 55%)
  • nullnull
Gene names: BHLHE75, LXRB, NCOA2, NER, NR1H2, SRC2, TIF2, UNR
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor
Nuclear receptor coactivator 2; Retinoic acid receptor RXR-beta Chains: B, F
Molecule details ›
Chains: B, F
Length: 255 amino acids
Theoretical weight: 28.11 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P28702 (Residues: 293-528; Coverage: 44%)
  • Canonical: Q15596 (Residues: 687-699; Coverage: 1%)
  • nullnull
Gene names: BHLHE75, NCOA2, NR2B2, RXRB, SRC2, TIF2
Sequence domains: Ligand-binding domain of nuclear hormone receptor

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P212121
Unit cell:
a: 68.637Å b: 101.221Å c: 143.274Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.21 0.208 0.248
Expression system: Escherichia coli BL21(DE3)