PDBe 5i3o

X-ray diffraction
2.4Å resolution

Crystal Structure of BMP-2-inducible kinase in complex with an Indazole inhibitor

Released:
Source organism: Homo sapiens
Entry authors: Counago RM, Sorrell FJ, Krojer T, Savitsky P, Elkins JM, Axtman A, Drewry D, Wells C, Zhang C, Zuercher W, Willson TM, Arrowsmith CH, Edwards AM, Bountra C, Arruda P, Gileadi O, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
BMP-2-inducible protein kinase Chains: A, B
Molecule details ›
Chains: A, B
Length: 302 amino acids
Theoretical weight: 34.01 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9NSY1 (Residues: 42-343; Coverage: 26%)
Gene names: BIKE, BMP2K, HRIHFB2017
Sequence domains: Protein kinase domain

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P43212
Unit cell:
a: 78.249Å b: 78.249Å c: 255.382Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.196 0.193 0.255
Expression system: Escherichia coli BL21(DE3)