› 5hk2

X-ray diffraction
3.2Å resolution

Human sigma-1 receptor bound to 4-IBP

Released:
DOI: 10.2210/pdb5hk2/pdb
PDB entry 5hk2 coloured by chain, front view.
PDB entry 5hk2 coloured by chain, side view.
PDB entry 5hk2 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the human σ1 receptor.
Schmidt HR, Zheng S, Gurpinar E, Koehl A, Manglik A, Kruse AC
Nature 532 527-30 (2016)
PMID: 27042935

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189257 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sigma non-opioid intracellular receptor 1 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 227 amino acids
Theoretical weight: 25.45 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q99720 (Residues: 1-223; Coverage: 100%)
Gene names: AAG8, OPRS1, SIGMAR1, SRBP
Sequence domains: ERG2 and Sigma1 receptor like protein

Ligands and Environments

3 bound ligands:
Ligand 61V 3 x 61V
Ligand SO4 12 x SO4
Ligand OLC 7 x OLC
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: P21212
Unit cell:
a: 85.7Å b: 126.8Å c: 110.8Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.222 0.218 0.261
Expression system: Spodoptera frugiperda

Quick links

Citations

54 review citations

Perturbations of Native Membrane Protein Structure in Alkyl Phosphocholine Detergents: A Critical Assessment of NMR and Biophysical Studies.
Chipot et al. (2018)
53 more

26 mentions without citation

Sigma Receptors as Endoplasmic Reticulum Stress "Gatekeepers" and their Modulators as Emerging New Weapons in the Fight Against Cancer.
Tesei et al. (2018)
25 more