PDBe 5hk2

X-ray diffraction
3.2Å resolution

Human sigma-1 receptor bound to 4-IBP

Source organism: Homo sapiens

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Sigma non-opioid intracellular receptor 1 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 227 amino acids
Theoretical weight: 25.45 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Canonical: Q99720 (Residues: 1-223; Coverage: 100%)
Gene names: AAG8, OPRS1, SIGMAR1, SRBP
Sequence domains: ERG2 and Sigma1 receptor like protein

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: P21212
Unit cell:
a: 85.7Å b: 126.8Å c: 110.8Å
α: 90° β: 90° γ: 90°
R R work R free
0.222 0.218 0.261
Expression system: Spodoptera frugiperda