PDBe 5hi7

X-ray diffraction
2.15Å resolution

Co-crystal structure of human SMYD3 with an aza-SAH compound

Released:

Function and Biology Details

Reaction catalysed:
S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Histone-lysine N-methyltransferase SMYD3 Chain: A
Molecule details ›
Chain: A
Length: 432 amino acids
Theoretical weight: 49.54 KDa
Source organism: Homo sapiens
Expression system: unidentified baculovirus
UniProt:
  • Canonical: Q9H7B4 (Residues: 1-428; Coverage: 100%)
  • Best match: Q9H7B4-3 (Residues: 1-369)
Gene names: SMYD3, ZMYND1, ZNFN3A1
Sequence domains:
Structure domains:

Ligands and Environments


Cofactor: Ligand 62X 1 x 62X
3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-D
Spacegroup: P212121
Unit cell:
a: 60.47Å b: 66.401Å c: 104.851Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.2 0.198 0.226
Expression system: unidentified baculovirus