PDBe 5hez

X-ray diffraction
2.66Å resolution

JAK2 kinase (JH1 domain) mutant P1057A in complex with TG101209

Released:

Function and Biology Details

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo octamer
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase JAK2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 302 amino acids
Theoretical weight: 35.46 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O60674 (Residues: 833-1132; Coverage: 27%)
Gene name: JAK2
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

3 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-G
Spacegroup: C222
Unit cell:
a: 211.813Å b: 215.649Å c: 91.497Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.218 0.217 0.238
Expression system: Spodoptera frugiperda