PDBe 5hen

X-ray diffraction
1.79Å resolution

Crystal structure of the N-terminus R100L bromodomain mutant of human BRD2

Source organism: Homo sapiens
Entry authors: Tallant C, Lori C, Pasquo A, Chiaraluce R, Consalvi V, Newman JA, von Delft F, Arrowsmith CH, Edwards AM, Bountra C, Knapp S

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Bromodomain-containing protein 2 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 126 amino acids
Theoretical weight: 14.87 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P25440 (Residues: 71-194; Coverage: 16%)
  • Best match: P25440-4 (Residues: 1-74)
Gene names: BRD2, KIAA9001, RING3
Sequence domains: Bromodomain
Structure domains: Bromodomain-like

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: C2
Unit cell:
a: 115.381Å b: 55.757Å c: 68.451Å
α: 90° β: 94.76° γ: 90°
R R work R free
0.183 0.181 0.223
Expression system: Escherichia coli