PDBe 5h65

X-ray diffraction
2.1Å resolution

Crystal structure of human POT1 and TPP1

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Protection of telomeres protein 1 Chain: A
Molecule details ›
Chain: A
Length: 294 amino acids
Theoretical weight: 33.31 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9NUX5 (Residues: 341-634; Coverage: 46%)
Gene name: POT1
Adrenocortical dysplasia protein homolog Chain: B
Molecule details ›
Chain: B
Length: 53 amino acids
Theoretical weight: 5.44 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q96AP0 (Residues: 266-316; Coverage: 9%)
Gene names: ACD, PIP1, PTOP, TINT1, TPP1

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL18U1
Spacegroup: P212121
Unit cell:
a: 49.231Å b: 87.824Å c: 87.12Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.199 0.196 0.248
Expression system: Escherichia coli BL21(DE3)