PDBe 5fy8

X-ray diffraction
2.34Å resolution

Crystal structure of human JMJD2A in complex with D-threo-isocitrate

Source organism: Homo sapiens
Entry authors: Nowak R, Kopec J, Johansson C, Szykowska A, Von Delft F, Arrowsmith CH, Bountra C, Edwards A, Oppermann U

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Lysine-specific demethylase 4A Chains: A, B
Molecule details ›
Chains: A, B
Length: 381 amino acids
Theoretical weight: 44.33 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: O75164 (Residues: 1-359; Coverage: 34%)
Gene names: JHDM3A, JMJD2, JMJD2A, KDM4A, KIAA0677
Sequence domains:

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P21212
Unit cell:
a: 100.93Å b: 148.91Å c: 57.05Å
α: 90° β: 90° γ: 90°
R R work R free
0.187 0.185 0.229
Expression system: Escherichia coli BL21(DE3)