PDBe 5ffo

X-ray diffraction
3.49Å resolution

Integrin alpha V beta 6 in complex with pro-TGF-beta

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero octamer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Integrin alpha-V heavy chain Chains: A, E
Molecule details ›
Chains: A, E
Length: 601 amino acids
Theoretical weight: 65.98 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: NEW P06756 (Residues: 31-429, 430-627; Coverage: 59%)
Gene names: ITGAV, MSK8, VNRA, VTNR
Sequence domains: FG-GAP repeat
Structure domains:
Integrin beta-6 Chains: B, F
Molecule details ›
Chains: B, F
Length: 257 amino acids
Theoretical weight: 28.85 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: NEW P18564 (Residues: 128-378; Coverage: 33%)
Gene name: ITGB6
Sequence domains: Integrin beta chain VWA domain
Transforming growth factor beta-1 proprotein Chains: C, D, G, H
Molecule details ›
Chains: C, D, G, H
Length: 363 amino acids
Theoretical weight: 41.49 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: NEW P01137 (Residues: 34-390; Coverage: 99%)
Gene names: TGFB, TGFB1
Sequence domains: Transforming growth factor beta like domain
Structure domains: Jelly Rolls

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P1
Unit cell:
a: 81.44Å b: 91.44Å c: 131.03Å
α: 89.98° β: 86.25° γ: 89.85°
R-values:
R R work R free
0.226 0.224 0.277
Expression system: Homo sapiens