PDBe 5ezp

X-ray diffraction
2.5Å resolution

Human transthyretin (TTR) complexed with 4-hydroxy-chalcone

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transthyretin Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 122 amino acids
Theoretical weight: 13.36 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P02766 (Residues: 26-147; Coverage: 96%)
Gene names: PALB, TTR
Sequence domains: HIUase/Transthyretin family
Structure domains: Transthyretin/hydroxyisourate hydrolase domain

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 2
Spacegroup: P31
Unit cell:
a: 62.48Å b: 62.48Å c: 238.32Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.212 0.21 0.245