PDBe 5etf

X-ray diffraction
2.4Å resolution

Structure of dead kinase MAPK14 with bound the KIM domain of MKK6

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Mitogen-activated protein kinase 14 Chain: A
Molecule details ›
Chain: A
Length: 360 amino acids
Theoretical weight: 41.37 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q16539 (Residues: 1-360; Coverage: 100%)
Gene names: CSBP, CSBP1, CSBP2, CSPB1, MAPK14, MXI2, SAPK2A
Sequence domains: Protein kinase domain
Structure domains:
Dual specificity mitogen-activated protein kinase kinase 6 Chain: B
Molecule details ›
Chain: B
Length: 15 amino acids
Theoretical weight: 1.63 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P52564 (Residues: 4-18; Coverage: 5%)
Gene names: MAP2K6, MEK6, MKK6, PRKMK6, SKK3

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: P3121
Unit cell:
a: 82.383Å b: 82.383Å c: 123.335Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.166 0.163 0.231
Expression systems:
  • Escherichia coli
  • Not provided