PDBe 5ep6

X-ray diffraction
1.45Å resolution

The crystal structure of NAP1 in complex with TBK1

Released:

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
5-azacytidine-induced protein 2 Chains: A, C
Molecule details ›
Chains: A, C
Length: 47 amino acids
Theoretical weight: 5.63 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9H6S1 (Residues: 215-255; Coverage: 11%)
Gene names: AZI2, NAP1, TBKBP2
Serine/threonine-protein kinase TBK1 Chains: B, D
Molecule details ›
Chains: B, D
Length: 58 amino acids
Theoretical weight: 6.32 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UHD2 (Residues: 677-729; Coverage: 7%)
Gene names: NAK, TBK1

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P212121
Unit cell:
a: 41.36Å b: 50.113Å c: 84.416Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.188 0.187 0.217
Expression system: Escherichia coli