PDBe 5enb

X-ray diffraction
1.73Å resolution

Crystal structure of the second bromodomain of Pleckstrin homology domain interacting protein (PHIP) in complex with o-Tolylthiourea (SGC - Diamond I04-1 fragment screening)

Released:

Function and Biology Details

Biochemical function:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
PH-interacting protein Chain: A
Molecule details ›
Chain: A
Length: 131 amino acids
Theoretical weight: 15.59 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8WWQ0 (Residues: 1315-1440; Coverage: 7%)
Gene names: PHIP, WDR11
Sequence domains: Bromodomain

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: P21212
Unit cell:
a: 60.3Å b: 92.17Å c: 24.25Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.213 0.212 0.236
Expression system: Escherichia coli