PDBe 5ejc

X-ray diffraction
3.1Å resolution

Crystal structural of the TSC1-TBC1D7 complex

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
TBC1 domain family member 7 Chains: A, B
Molecule details ›
Chains: A, B
Length: 276 amino acids
Theoretical weight: 32.26 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9P0N9 (Residues: 18-293; Coverage: 94%)
Gene names: HSPC239, TBC1D7, TBC7
Sequence domains: Rab-GTPase-TBC domain
Structure domains:
Hamartin Chains: C, D, E, F
Molecule details ›
Chains: C, D, E, F
Length: 55 amino acids
Theoretical weight: 6.27 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q92574 (Residues: 939-992; Coverage: 5%)
Gene names: KIAA0243, TSC, TSC1

Ligands and Environments

No bound ligands

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.1
Spacegroup: C2
Unit cell:
a: 183.395Å b: 66.704Å c: 98.37Å
α: 90° β: 91.91° γ: 90°
R-values:
R R work R free
0.221 0.22 0.239
Expression system: Escherichia coli