PDBe 5ehc

X-ray diffraction
2.4Å resolution

Co-crystal structure of eIF4E with nucleotide mimetic inhibitor.


Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Eukaryotic translation initiation factor 4E Chain: A
Molecule details ›
Chain: A
Length: 217 amino acids
Theoretical weight: 25.13 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: P06730 (Residues: 1-217; Coverage: 100%)
Gene names: EIF4E, EIF4EL1, EIF4F
Sequence domains: Eukaryotic initiation factor 4E
Structure domains: RNA Cap, Translation Initiation Factor Eif4e
Eukaryotic translation initiation factor 4 gamma 1 Chain: B
Molecule details ›
Chain: B
Length: 14 amino acids
Theoretical weight: 1.85 KDa
Source organism: Homo sapiens
Expression system: Not provided
  • Canonical: Q04637 (Residues: 609-622; Coverage: 1%)
Gene names: EIF4F, EIF4G, EIF4G1, EIF4GI

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Unit cell:
a: 38.489Å b: 52.177Å c: 125.698Å
α: 90° β: 90° γ: 90°
R R work R free
0.22 0.218 0.264
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided